---
title: Regulated Chemicals | Controlled Substance Lists | Scitegrity
description: Controlled Substances Squared is software system quickly that screens Regulated Chemicals against a Controlled Substance Lists. Click here to learn more.
---
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# Identification of **controlled substances**
## **Check Controlled Substance lists globally with Controlled Substances Squared**
Enter a chemical name, upload or draw your chemical structure to know if its regulated.
Or better yet, have Controlled Substances Squared constantly monitor all your chemical collections and alert you if something you should know about is present.
When you have a large chemical collection, identifying which ones are controlled is an important but difficult compliance challenge with many different regulations to consider including narcotics, psychotropics, chemical weapons, ozone depleting, export restricted and more.
Controlled Substances Squared is a software system, updated weekly, which can quickly screen even the largest chemical collections of millions of chemicals for regulated chemicals against controlled substance lists from around the world.
[Book Demo](https://www.scitegrity.com/demo-request?hsLang=en)
## Key Features
Tells you if, how and where your chemical is regulated or controlled. Checks all legislative requirements such as all ethers, esters, salts, stereoisomers, analogues and controlled areas of chemical space.
**Comprehensive**
Covers over 28 countries & international conventions for controlled drugs, chemical weapons and precursors, ozone depleting and export controlled chemicals.
**Check any chemical fast**
Works on proprietary & novel chemicals. Upload tens of thousands of chemicals in a single check (.sd, smiles and inchi). Or search by chemical or common name.
**Powerful yet simple to use**
Easy to use and understand, even if you’re not a chemist or compliance expert. But within a single click access detailed technical information, guidance documents and more.
## Upload, draw or search for your chemical structure
### Webservices
Automate checks via RESTful, Knime and Pipeline Pilot.
### Instant access
Web based with nothing to install.
### Support
Our experts are on hand for guidance and help.
### Alerts
To both to upcoming legislation and if your substances regulated status changes.
---
## Availability **Options**
### Cloud-based
Fully managed by Scitegrity. Nothing to install. Our Business plan is ideal for SME’s and includes access to our web based front end, webservices and technical support on aper user basis. For larger organisations our Cloud enterprise plan includes dedicated servers, unlimited users, enterprise authentication, advanced APIs, near instant searches even for millions of chemicals and automatic alerts when your compounds change controlled status via our FastLookup™ plus the ability to create your own rules and SOPs and much more.
[Start Now](https://www.scitegrity.com/contact?hsLang=en)
### On-premise
Only available for the Enterprise version. All the features of the cloud based version except deployed onto your own servers and integrated to constantly check your compound inventories for regulated substances. Being behind your firewall your compound structures never leave your company, but weekly updates are still automatically downloaded and applied, your inventories rechecked and you are alerted to compliance issues.
[Start Now](https://www.scitegrity.com/contact?hsLang=en)
## **Coverage**
### National controlled drug legislation
**Controlled substance lists** from:- Argentina, Austria, Belgium, Brazil, Canada, China, Denmark, Finland, France, Germany, India, Indonesia, Ireland, Italy, Japan, Norway, Mexico, Netherlands, Norway Poland, Saudi Arabia, Singapore, Slovakia, Spain, Sweden, Switzerland, Taiwan, United Kingdom\*, United States of America\*
[Start Now](https://www.scitegrity.com/contact?hsLang=en)
### Regional and international agreements
Chemical Weapons Convention (including the Australia Group)
European Union\* (Controlled Drug precursors, military dual use, human rights lists)
Montreal Ozone Protocol
PIC / Rotterdam Convension
UN (INCB)
Wassenaar Arrangement
World Anti-Doping Agency lists
\*also includes strategic export control regulations on chemicals such ITAR, CCL, dual use etc.
[Start Now](https://www.scitegrity.com/contact?hsLang=en)
## Commonly-asked **Questions**
### Can’t I just check a chemical name against controlled substances lists such as those on the DEA (US) or HomeOffice website (UK)
All legislation defines areas of controlled chemical space instead in addition to named substances. These can be as simple as all ethers or esters of the named substance, to complex definitions known as**[‘generic statements’, ‘chemical family controls’ or ‘Markush statements’](https://blog.scitegrity.com/news/controlled-substances-lists-and-chemical-families?hsLang=en)** and its essential to search these to ensure compliance. Simply checking against lists of names will lead to serious compliance issues as these are just examples of the chemicals actually under control. You can read more about this in our series of **[blog posts](https://blog.scitegrity.com/news/controlled-substance-lists?hsLang=en)**
### I’m using small amount (mg’s) for research and development, do I still need to treat them as controlled.
Yes. In general R&D is not except (or every illicit transaction would be for ‘R&D purposes’). There are a few limited exemptions and these vary depending on country, but generally cannot be relied upon (read our blog on **[this here](https://blog.scitegrity.com/resources/research-exemptions-for-controlled-substances?hsLang=en)**). The good news is that with the right site licence you can still use, supply or ship them as long as you keep good records and know what is and isn’t controlled.
### Why is it called Controlled Substances Squared
In the United Kingdom, to say something is 'squared' can mean a problem is fixed, solved or taken care of. Controlled Substances Squared (CS2) takes care of your problem of indentifying any regulated substances you have.
### Can you help us understand and be compliant with the US analogues act.
Yes, certainly. Please contact us. You can also read our blog about it **[here](https://blog.scitegrity.com/news/list-of-controlled-drugs-and-analogues?hsLang=en)**
### Can you help us check controlled drug lists in the USA, UK, Switzerland and Europe
Yes, this is exactly what Controlled Substances Squared does. Please contact us for a demo and discussion. You can also read our series of**[blog posts](https://blog.scitegrity.com/news/controlled-substance-lists-0?hsLang=en)**here on pitfuls to avoid when checking lists of scheduled substances.
### Are you just controlled drugs
No, we cover lots of other regulations such as ITAR and CCL in the USA, EU / UK export controls lists, PIC Rotterdam, Ozone depleting substances the chemicals weapons convension and more.
### What countries do you cover and can you add more
We are always adding more countries and regulations. If you have a specific requirement please contact us.
### Are controlled drugs regulated at the EU level with Europe
In short no. Controlled drug lists are defined at the national level in the EU. To be compliant you much check the national legislation of the country you are shipping to and from. Drug precursors laws and some export control substances are harmonised and regulated at the EU level, but controlled drug lists and defined at the national level and vary significantly between EU countries (as well as globally).
## Get our **Chemicals Compliance Whitepaper**
## Trusted by our **Clients**
## What our **clients **are saying****
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### Director Research Informatics & Operations
LundBeck
“We implemented Controlled Substances Squared (CS2) in our workflow about 2 years ago. The software checks compounds upon registration from our chemists internally and externally. Each compound is then treated accordingly by our compound management staff. This software has had a great impact in helping us monitoring our controlled substances across multiple jurisdictions, which was for us a difficult process in the past.”
### Controlled Chemicals Lead
Big 10 Pharma Company
“We have utilised Scitegrity’s Controlled Substances Squared (CS2) solution for several years now as our enterprise-wide mechanism for identifying controlled substances. Scitegrity’s staff continually display outstanding customer focus in working with us for integrations with internal applications, answering questions about functionality, and anything else that comes up-all in a timely fashion. Their expertise in the regulations has also been invaluable, as they provide alerts to regulatory changes and are available to answer specific queries that arise internally from scientists or management. I have been very pleased with the decision to work with Scitegrity and would endorse them, and their products, to others.”
### Steven Miller, Chief Scientific Officer
Catalyst Pharmaceuticals
“As part of Catalyst efforts to develop a new CNS drug, Scitegrity performed a quantitative chemical similarity test between our drug an all schedule I through V controlled substances. In a matter of weeks, Scitegrity completed this work and prepared a report suitable for NDA submission and review by the FDA’s controlled substances staff. In addition, the speed and high quality, it was conducted with minimal oversight and interaction with Scitegrity. It is nice to have a contractor that just gets things done right and leaves one less thing to worry about during the drug development process.”
### Deputy Head of Research Products, BioSynth
“The software is great (Compliance Hub, including Controlled Substances Squared & ExpediChem) and I have no idea how we managed before”
### Head of Compound Management
Boehringer Ingelheim
"Boehringer Ingelheim use Scitegrity’s Controlled Substances Squared system to provide controlled substance compliance at all stages of R&D operation. The weekly legislation updates that are automatically checked against the compound collections ensure permanent compliance with the latest laws, while its integration with synthesis and procurement systems ensure all new compounds are checked.” - Head of Compound Management, Boehringer
### Lundbeck A/S
Safety Pharmacology
"In relation to development and filing of a new CNS drug, we used the experience and expertise of Scitegrity to perform an analysis of the structural similarity of our compound to US schedule 1 to 5 compounds as part of Lundbeck’s wider Drug Abuse Potential Assessment. Scitegrity provided expert input to the assessment, provided a high quality report and allowed us to progress development in a timely manner."
### William Hapworth
President, Neuritek Therapeutics AG
"In support of Neuritek’s development of a new CNS drug, Scitegrity performed a comprehensive chemical similarity assessment to compounds controlled under Schedules 1-5 of the United States Controlled Substances Act. The work was done quickly, precisely and with outstanding diligence. The interactions with the Scitegrity team were nothing but pleasant. The report was clear, provided the necessary data to answer the scientific questions and supported our efforts of de-risking and progressing with our drug development program"****
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